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Doxacurium chloride
Doxacurium chloride (formerly recognized as BW938U80 or BW A938U) is a neuromuscular-blocking drug or skeletal muscle relaxant in the category of non-depolarizing neuromuscular-blocking drugs, used adjunctively in anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. Unlike a number of other related skeletal muscle relaxants, it is rarely used adjunctively to facilitate endotracheal intubation.
==Chemistry==
Doxacurium is a symmetrical molecule because it is a diester of succinic acid.
The pharmacological action of doxacurium is a function of its competitive antagonism to acetylcholine receptors of the nicotinic type. The drug is marketed worldwide under the tradename of Nuromax, and it is classified as a long-duration non-depolarizing neuromuscular blocking agent in a class of compounds commonly and most erroneously referred to as "benzylisoquinolines" when, in fact, it is a ''bis''benzyltetrahydroisoquinolinium agent.
The pharmaceutical preparation comprises the three trans-trans isomers (a meso structure ''R'',''S''-''S'',''R''-doxacurium and an enantiomeric pair ''R'',''S''-''R'',''S''-doxacurium and ''S'',''R''-''S'',''R''-doxacurium)
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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